US 5,545,807 · Granted 1996-08-13
Production of antibodies from transgenic animals
Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an immunoglobulin, of foreign origin or that can rearrange to encode a repertoire of immunoglobulins, i.e. derived from a different animal source. For example, wholly human immunoglobulins may be produced from a transgenic mouse, possibly in response to an immunogen subsequently introduced to the mouse.
Patent details
- Publication number
- US 5,545,807
- Filing date
- 1994-08-05
- Grant date
- 1996-08-13
- Assignee
- The Babraham Institute / Medical Research Council
- Inventor(s)
- SURANI; AZIM M., NEUBERGER; MICHAEL S., BRUGGEMANN; MARIANNE
- CPC class
- C12N15/8509
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