US 2,010,218,264 · Filed 2009-12-03
Genome editing in rats using zinc-finger nucleases
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
Patent details
- Publication number
- US 2,010,218,264
- Filing date
- 2009-12-03
- Grant date
- Application — not yet granted
- Assignee
- Sangamo Biosciences, Inc. / Sigma Aldrich Company
- Inventor(s)
- CUI XIAOXIA, GEURTS ARON M., URNOV FYODOR
- CPC class
- A01K67/0275
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