US 5,175,384 · Granted 1992-12-29
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.
Patent details
- Publication number
- US 5,175,384
- Filing date
- 1988-12-05
- Grant date
- 1992-12-29
- Assignee
- Genpharm International
- Inventor(s)
- KRIMPENFORT; PAULUS J. A., BERNS; ANTONIUS J. M.
- CPC class
- A01K67/0275
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