US 5,614,396 · Granted 1997-03-25
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
A method for producing animal cells, chimeric or transgenic non-human animals which contain a desired gene sequence inserted into a predetermined gene sequence. The method permits the production of animal cells and non-human animals which have subtle and precise modifications of gene sequence and expression relative to natural non-human animals.
Patent details
- Publication number
- US 5,614,396
- Filing date
- 1994-02-22
- Grant date
- 1997-03-25
- Assignee
- Baylor College Of Medicine
- Inventor(s)
- BRADLEY; ALLAN, DAVIS; ANN, HASTY; PAUL
- CPC class
- A01K67/0275
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