US 5,741,957 · Granted 1998-04-21
Transgenic bovine
A transgenic bovine is disclosed whose somatic and germ cells contain a transgene, wherein the transgene comprising a mammary gland specific promoter, a mammary gland specific enhancer, a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells and a DNA sequence encoding a heterologous polypeptide of interest wherein the transgenic bovine expresses the transgene such that the polypeptide of interest is detectable in milk produced by the transgenic bovine.
Patent details
- Publication number
- US 5,741,957
- Filing date
- 1995-06-05
- Grant date
- 1998-04-21
- Assignee
- Pharming B.V.
- Inventor(s)
- DEBOER; HERMAN A., STRIJKER; REIN, HEYNEKER; HERBERT L., PLATENBURG; GERARD, LEE; SANG HE, PIEPER; FRANK, KRIMPENFORT; PAUL J. A.
- CPC class
- C12N15/8509
Want to file your own patent?
Run your idea through our free scanner — we’ll show you which existing patents are conceptually closest, including this one if it’s a match.
Free patentability scanRelated patents in this cluster
- US 5,633,425: Transgenic non-human animals capable of producing heterologous antibodies
- US 5,545,807: Production of antibodies from transgenic animals
- US 5,661,016: Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
- US 6,075,181: Human antibodies derived from immunized xenomice