US 5,750,172 · Granted 1998-05-12
Transgenic non human mammal milk
This invention relates to the production of recombinant proteins, such as coagulation factors VIII and IX, tissue plasminogen activator (TPA), urokinase, growth hormone, insulin, interferons, interleukins, peptide hormones and immunoglobulins, in mammals' milk. Particularly, this invention relates to an expression system which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This invention also relates to the transgenic mammal that produces the desired recombinant product in its milk.
Patent details
- Publication number
- US 5,750,172
- Filing date
- 1995-06-05
- Grant date
- 1998-05-12
- Assignee
- Pharming B.V.
- Inventor(s)
- MEADE; HARRY, LONBERG; NILS
- CPC class
- C12N15/8509
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