US 6,023,010 · Granted 2000-02-08
Transgenic non-human animals depleted in a mature lymphocytic cell-type
Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
Patent details
- Publication number
- US 6,023,010
- Filing date
- 1996-12-05
- Grant date
- 2000-02-08
- Assignee
- Genpharm International
- Inventor(s)
- KRIMPENFORT; PAULUS JACOBUS ANGELINUS, BERNS; ANTONIUS JOHANNES MARIA
- CPC class
- A01K67/0275
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