US 6,352,859 · Granted 2002-03-05
Evolution of whole cells and organisms by recursive sequence recombination
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Patent details
- Publication number
- US 6,352,859
- Filing date
- 2000-07-26
- Grant date
- 2002-03-05
- Assignee
- Maxygen, Inc.
- Inventor(s)
- DELCARDAYRE STEPHEN, TOBIN MATTHEW, STEMMER WILLIAM P. C., NESS JON E., MINSHULL JEREMY, PATTEN PHILLIP, SUBRAMANIAN VENKITESWATAN, CASTLE LINDA, KREBBER CLAUS M., BASS STEVE
- CPC class
- C12N15/1027
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