US 6,511,824 · Granted 2003-01-28
Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use
Tandem pore domain weak inward rectifying K + (TWIK) channel nucleic acids and proteins that have been isolated from Drosophila melanogaster and Leptinotarsa are described. The TWIK channel nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects, coelomates, and pseudocoelomates, or cultured cells, resulting in TWIK channel expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with TWIK channel proteins. They can also be used in methods for studying TWIK channel activity and identifying other genes that modulate the function of, or interact with, the TWIK channel gene.
Patent details
- Publication number
- US 6,511,824
- Filing date
- 1999-07-28
- Grant date
- 2003-01-28
- Assignee
- Exelixis, Inc.
- Inventor(s)
- BUCHMAN ANDREW ROY, BURKS CHRISTIAN, FRANCIS-LANG HELEN LOUISE, GILLETT LUCILE A., HELLER JONATHAN CAGAMPANG, KOPCZYNSKI CASEY CASIMIR, MARGOLIS JONATHAN SCOTT, PLATT DARREN MARK, REDDY BINDU PRIYA, SWIMMER CANDACE, WINSLOW JOHN W., LUO YULING
- CPC class
- C07K14/43581
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