US 7,629,170 · Granted 2009-12-08
Evolution of whole cells and organisms by recursive sequence recombination
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
Patent details
- Publication number
- US 7,629,170
- Filing date
- 2006-08-17
- Grant date
- 2009-12-08
- Assignee
- Maxygen, Inc.
- Inventor(s)
- DELCARDAYRE STEPHEN, TOBIN MATTHEW B., STEMMER WILLEM P. C., NESS JON E., MINSHULL JEREMY S., PATTEN PHILLIP A., SUBRAMANIAN VENKITESWATAN MANI, CASTLE LINDA A., KREBBER CLAUS M., BASS STEVEN H., ZHANG YING-XIN, COX ANTHONY R., HUISMAN GJALT W., YUAN LING, AFFHOLTER JOSEPH A.
- CPC class
- C12N1/205
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